Proven Anti-Inflammatory

are clinically proven to dilate blood vessels, inhibit inflammation, platelet adhesion, and oxidative damage through the production of Nitric Oxide and cGMP.

How it Works

Research has demonstrated that the ingredients in CRYODERM stimulate nitric oxide (NO) formation through activation of Ca2+/calmodulin-dependent protein kinase (CaM kinase). Nitric oxide, in turn, binds to and activates guanylyl cyclase. This enzyme catalyzes the dephosphorylation of GTP to cyclic GMP (cGMP), which serves as a second messenger for signaling smooth muscle relaxation.

Image showing vascular effects of NOVascular effects of NO:

  • Direct vasodilation (flow dependent and receptor mediated)
  • Indirect vasodilation by inhibiting vasoconstrictor influences (e.g., inhibits angiotensin II and sympathetic vasoconstriction)
  • Anti-thrombotic effect - inhibits platelet adhesion to the vascular endothelium
  • Anti-inflammatory effect - inhibits leukocyte adhesion to vascular endothelium;
  • Anti-proliferative effect - inhibits smooth muscle hyperplasia
  • Scavenges free radicals, improving cellular health

cGMP: Cyclic GMP induces smooth muscle relaxation by multiple mechanisms including:

  • Increased intracellular cGMP, which inhibits calcium entry into the cell, and decreases intracellular calcium concentrations.
  • Activates K+ channels, which leads to hyperpolarization and relaxation
  • Stimulates a cGMP-dependent protein kinase that activates myosin light chain phosphatase, the enzyme that dephosphorylates myosin light chains, which leads to smooth muscle relaxation.
  • Induces smooth muscle relaxation
  • Inhibits blood clotting (platelet adhesion).